Diabetes - Amputation (2 case studies)

Case Study A: Treatment of diabetic angiopathy (diabetic foot, ulcers and gangrene)


Patient male 67 years old was admitted in the year 2005 for treatment with diagnosis of post amputation gangrene of the right thigh. The patient was amputated on the right leg above the knee joint. At the time of admission the condition of the patient was severe with ESR levels of 80, leucocytes =26 and severe pain in the amputated part of the leg. Local lymphadenopathy with considerable increase in size. The size of the lesion {gangrene} had deep and large pus, bad smell and the patient was in an intoxicated or confused state.

Brief history

The patient was diagnosed with diabetes mellitus type 2 about 16 years ago and was prescribed a combined therapy of insulin injections and oral tablets - Glucophage 500mg three times per day. About a year ago, before coming to our institute for treatment the patient was diagnosed with arterial block on the right leg. It was decided to undergo a surgical venoarterial graft transplant procedure with the graft segment to be harvested from the left healthy leg of the patient. The procedure was carried out but was a failure and the patient developed gangrene at the site of surgery resulting in the above said amputation. Antibiotic therapy for gangrene treatment was also not effective. The amputation also was not able to stop the gangrene from spreading to the right femoral region (thigh). The patient was discharged from the surgical department with conservative treatment and a poor prognosis.

Soon after the patient was brought to our institute where he was administered ozone therapy.


1st Day: 20 sessions of high dosage ozone I.V. two times per day. And also on the site of the gangrenous lesion topical ozone bag were applied to aid in faster wound healing. This ozone bag method was used to heal the outside pus and infection which had spread practically to the bone. For this the ozone dosage administered was also increased to twice of normal.

In 4 weeks of treatment initiation: In a month’s time there was visible wound healing and appearance and rehabilitation with healthy muscle mass and tone, tissue was also rehabilitated on the affected sites as earlier.

In 4 months: Due to this visible recovery the dosage of ozone being administered was decreased to two times per week and continued for another 30 sessions. And in the next four months the patient regained complete healthy tissue and muscular framework at the affected site. The only remaining physical sign is keloid cicatrix at the wound site.

Results For Case Study A:

Treatment Summary 

A leg prosthesis was provided to the patient and he now walks, drives a car and motorcycle. His life has returned to normality to the maximum extent. 

Five years after this therapy, the patient receives 10 sessions of ozone therapy as prophylaxis for the left leg from where venous graft was taken. Presently the patient’s condition is satisfactory.

Case Study B: Treatment of diabetic angiopathy B

Personal data, medical history:

Patient B, 83 y.o old male visited our clinic , Glucofage 500mg. 1tab.3 times in a day, Insulin (short acting). 

Physical status before treatment:

The extensive, postoperative wound. Big amount of pus and awful smell. 

Treatment description:

Ozone therapy combined with other kinds of treatment. 

Results For Case Study B:

Physical status after treatment:

Patient continued treatment until full recovery of the foot. Now the patient undergoes the same procedure twice a year.